Dissecting the Genetic Architecture of Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Status: Recruiting
Location: See location...
Intervention Type: Genetic
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The objective of this study is to characterize the genetic architecture of a large cohort of CIDP patients to evaluate whether specific alleles/haplotypes are implicated in the risk of CIDP, in its clinical and immunological variability, severity, therapeutic response, and association with diabetes and other autoimmune diseases. We will genotype \>700,000 single nucleotide polymorphisms (SNPs) by using the Illumina Global Screening Array (GSA), of approximately 1000 patients with CIDP. About 3500 healthy controls from the Italian population have been already genotyped using GWAS from our genetic department. Alleles/haplotypes will be also compared between patients with typical CIDP and its variants, between CIDP patients with and without specific antibodies, between CIDP patients with and without comorbidities, between CIDP patients with low and high levels of disability and between CIDP patients with and without response to each individual treatment (IVIg, steroids, plasma exchange)

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• \- Subject with a documented diagnosis of according to the EAN/PNS criteria

Locations
Other Locations
Italy
IRCCS Istituto Clinico Humanitas
RECRUITING
Rozzano
Contact Information
Primary
Pietro Emiliano Emiliano Doneddu, MD
pietro.doneddu@hunimed.eu
00390282247761
Time Frame
Start Date: 2022-11-15
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 3500
Treatments
Experimental: Chronic inflammatory demyelinating polyneuropathy (CIDP)
Single nucleotide polymorphisms (SNPs) of 1000 patients with chronic inflammatory demyelinating polyneuropathy will be genotyped using the Illumina Global Screening Array
Experimental: Control Subjects
Single nucleotide polymorphisms (SNPs) of 2500 control subjects without chronic inflammatory demyelinating polyneuropathy will be genotyped using the Illumina Global Screening Array
Sponsors
Leads: Istituto Clinico Humanitas

This content was sourced from clinicaltrials.gov